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Polymethoxylated Flavones PMFs

PMFs,Polymethoxylated Flavones,Citrus Flavonoid Compounds
Flavonoids are natural polyphenolic compounds found in a wide variety of fruits and vegetables. A subset of flavonoids known as polymethoxylated flavones ( PMF) have been shown to possess especially potent cardioprotective benefits.

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30%,60%,98% Polymethoxylated Flavones

PMFs,Polymethoxylated Flavones,Citrus Flavonoid Compounds
Flavonoids are natural polyphenolic compounds found in a wide variety of fruits and vegetables. A subset of flavonoids known as polymethoxylated flavones ( PMF) have been shown to possess especially potent cardioprotective benefits.

Polymethoxylated flavones—flavonoid compounds derived from the peels of oranges, tangerines, and other citrus fruits—are highly methoxylated and contain biologically active molecules with unique metabolic properties.

Two of the most-researched polymethoxylated flavones are nobiletin and tangeretin.

What are PMFs?

As aforesaid, Polymethoxylated Flavones are a group of natural polyphonic compounds known as flavonoids. PMF is derived from orange and tangerine peels, among other citrus fruits. These peels are often highly methoxylated and contain active biological molecules known to impact the metabolic processes in a positive way.

The popular use for PMFs is in lowering bad cholesterol LDL, although the compounds are also known to result in other health benefits, such as protection from inflammation, heart disease, and cancer.

How Pmfs Work in the Body

The discovery of PMFs impact on the body is not in any way new. Research studies done on animal subjects back in 2004 were quite positive. Based on the joint scientific research carried out by the US Agriculture Department and Canada’s KGK Synergize, PMFs can be a very effective alternative to reducing LDL and helping in cholesterol management.

Although cholesterol can be controlled through dieting by avoiding saturated and trans-fatty acids, this will only influence 20% as the remaining 80% of cholesterol is synthesized by the body in the liver. 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme that controls biosynthesis of cholesterol in the liver.

When there is low cholesterol in the blood, the liver produces more of this enzyme, thus increasing cholesterol synthesis. Conversely, high cholesterol in the blood triggers the liver to limit the production of this enzyme.

PMFs are highly methoxylated, which means one of the H-groups in the compound is replaced by CH2O. By taking PMF, the limiting enzyme production is lowered resulting in the reduction of LDL cholesterol synthesized.

Dietary choices are usually the major cause of disruption to the cholesterol synthesis process, increasing the production of HMG-CoA reductase. Using dietary supplements to deliverpolymethoxylated flavones is one way to counteract this effect.

Flavonoids also act in various other ways that include reducing oxidative drug metabolism, inhibiting LDL cholesterol oxidation, and inhibition of chemical carcinogenesis that often results in tumor development.

Uses of PMFs

Various uses have been identified for PMF supplements currently available in the market. Some uses have already been proven through research, while others are assumptions based on the health benefits shared by over 4,000 different flavonoids already known to man. Some of the popular uses for PMFs include the following:

According to the results from animal subjects, PMFs have already shown great success in the reduction of bad cholesterol LDL.

One of the great advantages is that PMFs achieve this without the associated side effects of conventional cholesterol lowering drugs like statins. There is no risk of liver disease or muscle weakness.

Reduced Risk for CVDs

With low LDL levels, patients with a high risk for cardiovascular diseases can forget about their preconditioning. PMFs have increased cardio-protective benefits and reduce the risk for heart disease and high blood pressure.

Improved Immune System

PMF supplements have been recommended to boost the immune system and increase protection from various kinds of diseases that arise from oxidative drug metabolism and cholesterol oxidation.

Reduced risk for cardiovascular diseases is also another form in which boosted immune system characterizes.

Cancer Treatment

Although research is still ongoing in this field, PMFs have been shown to possess potent anti-cancer characteristics.

Taking PMF supplements can thus reduce the risk of developing certain types of cell cancers. They also prevent chemical carcinogenesis and stunt the development of tumors.

Anti-Inflammation

Polymethoxylated flavonoids have anti-inflammatory properties and can help prevent and/or soothinflammations in different areas. Most supplements also include Vitamin C and other ingredients and antioxidants.

There are other uses of PMFs described in supplement labels and many benefits may also be identified.

Although some of the claims may be genuine, it is important to stick to your doctor’s recommendation and the proven uses.

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